Our course content is comprehensive and is based on the RCOG syllabus.
We urge you to be active in your learning, seeking the knowledge you need from most appropriate sources, rather than passively reading books from cover to cover. You need to decide what you need to learn (i.e. set objectives), decide where you will learn it from (select sources), and then learn. The detailed syllabus below provides you with list of topics you are expected to learn for your MRCOG part I exam. We have aimed to cover all the items on this list in our course. We encourage you to use this list to structure your revision (whether you come to our course or not!).
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Syllabus Item
SECTION 1: Anatomy
Pelvis and Perineum:
Bones
Vessels (Arteries/veins/lympahtics) | View Sample
Uterus
Cervix
Vagina & vulva
Fallopian tubes
Ovary
Broad ligament and peritoneum
Ureter
Bladder
Urethra
Sigmoid colon
Rectum
Anal sphincter | View Sample
Urogenital triangle
Superficial perineal pouch
Deep perineal pouch
Perineum
Abdomen:
Bones
Muscles
Vessels (Arteries/veins/lymphatics)
Nerves
GI tract
Hypothalamic-ovarian axis
SECTION 2: Embryology
Control of spermatogenesis & oogenesis
1st week of development:
Implantation
Trophoblast & Embryoblast
2nd week of development (bilaminar disc): | View Sample
3rd week of development (trilaminar disc): | View Sample
Origin of tissues:
Mesoderm
Neural crest derivatives
Development of the urogenital system
Development of the GI system
Development of the Circulatory system
Development of the neural system
SECTION 3: Statistics and Epidemiology
Critical appraisal of medical literature:
Therapy articles (RCTs)
Diagnostic studies (cross-sectional studies)
Systematic reviews and meta-analysis
Efficient literature searching
Summary measures for therapy (RR, OR, RD, NNT)
Summary measures for accuracy (sensitivity & specificity, predictive values, likelihood ratios)
Descriptive statistics (mean, median, mode, standard deviation, variance, standard error, confidence interval, interquartile ranges etc.)
Statistical tests (t-test, chi-square test, Fisher's exact test etc.)
Perinatal mortality statistics
Maternal mortality statistics (& Confidential Enquiry into Maternal Death Report)
Biochemistry
Proteins
Aminoacids
Peptides
Structure of proteins
Purification & analysis of proteins
Myoglobin & haemoglobin
Enzymes
Intracellular matrix
Carbohydrates & Lipids
Overview of Metabolism
Glycolysis
Kreb's (citric acid) cycle
Pentose phosphate pathway
Respiratory chain
Fatty acid oxidation
Regulation of metabolic pathways
Lipid transport & storage
Catabolism
Urea cycle
Haemoglobin
Other topics
Vitamins
Minerals
Nucleic acids
Eicosanoids
Steroidogeneses
Gap junctions
Nitric oxide signalling
Calcium as a messenger
Ion channels
Enzyme messenger systems
Placental function
Endocrinology
Hormones
Synthesis
Storage
Release
Transport
Mode & site of action
Pathological activity of hormones
Cell surface receptors
Nuclear receptors
Hormone types
Peptide hormones
Steroid hormones
Aminoacid hormones
Prostaglandins & leukotrines
Medical physics
biological effects of heat
biological effects of sound
biological effects of electromagnetic radiation
Ultrasound
Intensity
Impedence & reflection
Absorption
Diffraction
Focusing
Doppler effect
magnetic resonance imaging
Genetics And Cell Biology
Cell structure
Structural functional components
Cell cycle function
DNA replication
Mitosis and cell cycle
Differences from meiosis
Central dogma
DNA, RNA, Protein
DNA and RNA
Structure and Differences
Gene
Transcription
Translation – roles of mRNa, tRNA
Chromosome structure and function
Barr Bodies and X inactivation
Structural deletion vs chromosomal translocation disorders
Mendelian diseases
Autosomal dominant
Autosomal recessive
Sex linked X and Y
Genetic imprinting
Uniparental disomy
DNA and molecular techniques
PCR
Blotting-Northern, Southern, Western
Recombinant DNA techniques
Pre-implantation diagnosis
Microbiology
Classification
General microbiological classification
Virulence factors
Endotoxins
Exotoxins
Septic Shock
Toxic Shock syndrome
Bacteria
Gram stain classification
Streptococcus
Staphylococcus and MRSA
Clostridium
Listeria
Neisseriae
Pseudomonas aeruginosa
Viruses
DNA & RNA classification
CMV
VZV
HSV
Hepatitis A, B, C, D, E-key differences
Human Parvovirus B19
Rubella
HPV
HIV
Fungi
Candida
Aspergillus
Protozoa
Trichomonas vaginalis
Toxoplasma gondii
Atypical organisms
Chlamydia
Syphilis & VDRL test
Actinomycosis
Mycoplasma, Ureaplasma
TB and atypical Mycobacteria
Clinical application of knowledge In women and pregnancy
Commensals of femal genital tract
Vaginal discharge
Pelvic inflammatory disease
Urinary tract infection
Vertical transmission- Congenital intrauterine infections
Principles of infection control
Vaccination
Neonatal vaccination (HBV, ZIgG)
Sterilisation and Disinfection
Antibiotics safe in pregnancy
Pharmacology
General principles
Classification by receptors
Effects of :-
Parasympathetic vs. Sympathetic system
Nicotinic vs. Muscaranic Drugs
Hormone agonists and antagonists
Drugs related to pregnancy
Known teratogens
Breast feeding
Oxytocin
Prostaglandins
Corticosteroids
Sex steroids
Estrogen, Combined Pill, Combined HRT
Progestagens
Drug interactions
Anti-androgens, anti-oestrogens, SERMS/PRMS
Magnesium sulphate
Eclampsia
Important interactions
Prolactin and Dopamine
Dopamine agonists/antagonists
Beta blockers
In pregnancy
Beta blockers, diuretics, ACE inhibitors, Nifedipine
Prolong clotting
Warfarin and drug interactions
Aspirin
Heparin
Anti-cancer drugs
Classification
Major side effects
Anaesthetic drugs
Nicotinic and Muscaranic agents
Local and regional anaesthetic drugs
Ephedrine
Reproductive and Fetomaternal Physiology
Quick reminder
Meiosis function
Hormonal production
Estrogens, testosterone, progesterone
Male reproductive systems
Spermatogenesis
Female reproductive system
Oogenesis
Menstrual cycle
Puberty changes, precocious, delayed
Pregnancy physiology
CVS
Respiratory
Renal
Endocrine
GIT
Fetus and neonate
Fetal cardiovascular system and changes at birth
Embryological outcome of vessels
Quantitative knowledge of normal physiological variables
CVS
RS
Urine
Immunology and Haematology
Immunology
Definitions
Innate system
Cell Mediated- T cells, Macrophage functions
Humoral
Lymphoid system in adult
Pathological roles
Hypersensitivity Type 1, II, III, IV
Immunosuppression
Immunology of pregnancy, neonate and infant
Non-rejection of fetus
Fetal immune system
Jaundice
Rhesus disease
Haematology
Stem cells
Adult and fetal Haemoglobin and differing properties
Changes to dissociation curve
Haematology in pregnancy
Physiological dilution
Effect on blood components
Types of anaemia
Haemolytic
Haematinic deficiency
Rhesus disease and testing
Normal clotting system and pro-thrombotic states
Flow chart
Vitamin K sensitive
Pregnancy alterations
Warfarin, Heparin and Prothrombotic agents
Pathological haematology conditions
DIC
APLS
Pathology and Homoeostatis
Definitions
Metaplasia, dysplasia, neoplasia, hyperplasia, hypertrophy
Apoptosis, necrosis
Malignancy vs. benign cellular and genetic differences
Cancer
Carcinogens (infections, toxins)
Tumour factors or proteins released by tumours
Inflammation and trauma and regeneration
Acute and chronic inflammation
Primary and Secondary healing
Granulomatous inflammation
Therapeutic response
Radiotherapy
Normal haemostasis and pathological states for:
Water
Sodium, Potassium
Calcium
Acid
Endometrial changes in pregnancy
Decidualisation of stroma vs decidual cells
Common pathological conditions
Atherosclerosis
Osteoporosis and osteomalacia (Rickets)
Amyloidosis
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