John Ayuk MRCP

John is a senior SpR and honorary clinical research fellow working at the University Hospitals of Coventry and Warwickshire NHS Trust and The University of Birmingham. His main research interest involves the molecular and clinical basis of pituitary pathology, and his contribution in this field has resulted in him being invited to participate in the 5th consensus conference on guidelines for treatment of growth hormone excess and deficiency, being held in Santa Monica in February 2006.

He has a keen interest in medical education and has been involved in the delivery of tutorials and lectures to MRCP candidates at the University of Birmingham.


Below is a selection of his publications:

Publications in medical journals
  1. Ayuk J, Natarajan G, Geh JI, Mitchell RD, Gittoes NJ. 2005 Pituitary carcinoma with a single metastasis causing cervical spinal cord compression. Case report. J Neurosurg Spine.2(3):349-53.
  2. Ayuk J, Sheppard MC. 2004 The role of growth hormone-receptor antagonism in relation to acromegaly. Expert Opin Pharmacother. 5(11):2279-85.
  3. Ayuk J, McGregor EJ, Mitchell RD, Gittoes NJ. 2004 Acute management of pituitary apoplexy - surgery or conservative management? Clin Endocrinol (Oxf). 61(6):747-52.
  4. J Ayuk, MC Sheppard, RN Clayton, AS Bates, PM Stewart. 2004 Evidence for the Use of IGF-I as a Predictor of Mortality in Acromegaly Is Lacking. J Clin Endocrinol Metab. 89: 5867-68.
  5. Ayuk J, Clayton RN, Holder G, Sheppard MC, Stewart PM, Bates AS. 2004 Growth hormone and pituitary radiotherapy, but not serum insulin-like growth factor-concentrations, predict excess mortality in patients with acromegaly. J Clin Endocrinol Metab. 89(4):1613-7
  6. Ayuk J, Stewart SE, Stewart PM, Sheppard MC; European Sandostatin LAR Group. 2004 Efficacy of Sandostatin LAR (long-acting somatostatin analogue) is similar in patients with untreated acromegaly and in those previously treated with surgery and/or radiotherapy. Clin Endocrinol (Oxf). 60(3):375-81.
  7. EH Rabbitt, J Ayuk, K Boelaert, G Westin, MC Sheppard, M Hewison, PM Stewart, NJL Gittoes. 2003 Abnormal expression of 11Beta hydroxysteroid dehydrogenase type 2 in human pituitary adenomas: a prereceptor determinant of pituitary cell proliferation. Oncogene 20;22(11):1663-7
  8. J Ayuk, SE Stewart, PM Stewart, MC Sheppard.2002 Long-Term Safety and Efficacy of Depot Long-Acting Somatostatin analogues for Treatment of Acromegaly J Clin Endcocrinol Metab 87(9):4142-6.
  9. Ayuk J, Matthews T, Tayebjee M, Gittoes NJL. 2001 A Blind Panic (case report) The Lancet 357:1262
  10. Osman F, Ayuk J, Dale J, Franklyn JA, Gammage MD.2001 Thyrotoxicosis with heart block (case report) J R Soc Med 94:346-348
Book Chapters

Neil J.L. Gittoes, John Ayuk and Robin E. Ferner. Drug-induced diabetes, 26.1, in Textbook of Diabetes I, Third Edition, Edited by John c. Pickup and Gareth Williams, Blackwell Science Ltd 2003

Selected abstracts
  1. J Ayuk, SE Stewart, PM Stewart, MC Sheppard. Factors determining the use of primary medical therapy in acromegaly The Endocrine Society, San Diego 2005 (P1-525)
  2. J Ayuk, E McGregor, RD Mitchell, NJL Gittoes. Acute Management of Pituitary Apoplexy - Surgery or Conservative Management? The Endocrine Society, New Orleans 2004 (P1-403)
  3. J Ayuk, RN Clayton, MC Sheppard, PM Stewart, AS Bates. Impact of Comorbidity on Outcome in Acromegaly and its Association with Growth Hormone Hypersecretion and IGF-1 Levels The Endocrine Society, New Orleans 2004 (P1-382)
  4. J Ayuk, SE Stewart, MC Sheppard, PM Stewart. Association between serum insulin-like growth factor-1 and serum growth hormone levels across an oral glucose tolerance test in assessing disease activity in acromegaly British Endocrine Societies Meeting, Brighton 2004 (P87)
  5. J Ayuk, RN Clayton, MC Sheppard, PM Stewart, AS Bates. Cerebrovascular Mortality in Acromegaly is increased by the use of External Radiotherapy and is not predicted by elevated serum IGF1 The Endocrine Society, Philadelphia 2003 (OR7-6)
  6. J Ayuk , RN Clayton, MC Sheppard, PM Stewart, AS Bates. Outcomes In Acromegaly: A Retrospective Study of 419 Patients from the West Midlands Region of the United Kingdom The Endocrine Society, San Fransisco 2002 (P1-229)
  7. J Ayuk, E McGregor, J Mann, PM Stewart, AA Toogood. Growth Hormone
    Deficiency In Adults Treated For Acute Lymphoblastic Leukaemia In Childhood British Endocrine Societies Meeting, Harrogate 2002 (P204)
  8. J Ayuk, SE Stewart, PM Stewart, MC Sheppard. Long-acting somatostatin analogue
    is equally effective in untreated acromegalic patients and in patients previously
    treated with surgery/radiotherapy The Pituitary Society, Phoenix 2001 (Abstract 8)
  9. J Ayuk, K Boelaert, MC Sheppard, PM Stewart, NJL Gittoes. Switch in Expression of 11 Beta Hydroxysteroid Dehydrogenase mRNAs in Pituitary Adenomas The Endocrine Society, Denver 2001 (OR34-1)
  10. J Ayuk, SE Stewart, PM Stewart, MC Sheppard. Long-Term Safety and Efficacy of Depot Long-Acting Somatostatin analogues for Treatment of Acromegaly British Endocrine Societies Meeting, Belfast 2001 (P 45)
  11. Ayuk J, Bates AS, Holden N, Clayton RN, Sheppard MC, Stewart PM. A Prospective Study of an Initial Cohort of 274 Acromegalic Patients Drawn from a Single Health Authority District in the UK International Congress of Endocrinology, Sydney 2000 (OR 321)

 

Course Organisers

Arri Coomarasamy
Rajesh Varma
John Ayuk
Andrew Filer
Thomas Justin Clark

Course Director: Arri (Aravinthan) Coomarasamy MBChB, MD, MRCOG, DFFP
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